Disclaimer: This post was originally posted by Full Member, LinFL. This user is located in Zone 8b/9a border, NW FL. This was originally posted on February 3, 2015.
Another way to start sweet potato slips is to place the sweet potato on its side in a tray, bury it halfway in moist (not soggy) potting mix, and put it in a warm, well-lit spot. You can put several potatoes in a large tray if you want to make a lot of slips. Keep the potting mix consistently moist to get optimal slip production. My experience has been that the potting mix causes each sweet potato to produce more and faster slips than the water method. (YMMV.)
When the slips are at least 4" long, gently twist them off the sweet potato. You can place each slip in a large seed starting cell or small individual pot filled with moist potting mix. Place the slips in a shady warm spot and keep consistently moist - do not let the mix ever dry out - for a few days. Transition them back to higher light and grow on in the cells or pots until ready to transplant outside. The reason I like to root the slips in potting mix is so I can transplant them with an intact root ball instead of loose roots - they seem to suffer less shock that way. Just don't let them get root bound before planting.
If you are not experienced at starting plants indoors, please be aware that you need to gradually acclimate your plants to outside conditions, especially direct sunlight. Direct sunlight has much more UV than grow lights or light coming in through a window. You can literally sunburn the leaves of your plants and set back or even kill them if you transition them to full sun too fast. Place them in dappled shade or just a little early morning or late afternoon sun at first, then gradually increase sun exposure over several days to a week.